In Situ Sequencing (ISS), the 4th generation of DNA sequencing technologies
CARTANA’s technology is based on In Situ Sequencing (ISS), the 4th generation of DNA sequencing technologies. ISS is a new type of nucleic acid analysis performed directly on the tissue section, preserving the spatial information.
Ke, et al.: “In situ sequencing for RNA analysis in preserved tissue and cells” (2013, Nature methods)
Grundberg, et al: “In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics” (2013, Oncotarget)
Mignardi, et al: “Oligonucleotide gap-fill ligation for mutation detection and sequencing in situ” (2015, Nucleic Acids Research)
Ke, et al: “Fourth Generation of Next-Generation Sequencing Technologies: Promise and Consequences” (2016, Human Mutation)
Kühnemund, et al: “Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy” (2017, Nature Communications)
Xiaoyan Qian et al., “A spatial atlas of inhibitory cell types in mouse hippocampus“ (2018,
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